Sure it is OK to run with it on. It may or may not help with the pain. I recommend that you change the water you drink and shower in to best help with the pain. Many people that drink this patented water and shower with the patented shower head have had very positive results. Go here for the information on these life changing products: http://www.alkalinewaterfilters.net and http://www.dreamtreefamily.com/ggrice